Protein Details: Short transient receptor potential channel 5

Protein ID

ICDB_Pro_1670

Protein Name

Short transient receptor potential channel 5

Gene Name

TRPC5; TRP5

Organism

Homo sapiens (Human)

Length

973 amino acids

AlphaFoldDB

AF-Q9UL62-F1-model_v4.pdb

Function

Sequence

MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL

PDB Structures

6YSN 7D4P 7D4Q 7E4T 7WDB 7X6C 7X6I 8GVW 8GVX

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Autism Spectrum Disorder and Optic Atrophy 1

Location

TIExpressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. . . .

DOI ID

10.1006/geno.1999.5924; 10.1038/nature03440; 10.1101/gr.2596504; 10.1093/emboj/17.15.4274; 10.1073/pnas.102596199; 10.1074/jbc.m500391200; 10.1007/s00424-005-1419-1; 10.1113/jphysiol.2005.097998; 10.1016/j.ceca.2007.07.009; 10.1074/jbc.m109.068304; 10.3390/cells9030547; 10.1056/nejmoa1206524

RefSeq

NP_036603.1; XP_016885263.1